The Mixolydian mode on the guitar is a bluesy, classic rock scale with a dominant, driving sound that is highly popular across blues, country, and jam-band music. It is the fifth mode of the major scale, built by flattening only the seventh note of a standard major scale (1, 2, 3, 4, 5, 6, b7). Guitarists use this mode because its combination of a happy major third and a gritty flat seventh bridges the gap between major and minor sounds. It is the definitive scale for soloing over dominant seventh chords, powering iconic riffs by bands like the Grateful Dead, AC/DC, and the Allman Brothers.
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